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Unintentional overdose deaths, opioid deaths, and COVID-19 deaths among persons aged 25-44, per 100,000 person-month (vertical axis) by month (horizontal axis), stratified by HHS region. Bars: Unintentional drug overdose deaths (ICD10 X41-X45, Y11-Y15), 2018 (light blue with 95% CI) and opioid-specific drug overdose deaths (ICD10 X41-X45, Y11-Y15 and T40.0-40.6), 2018 (dark blue with 95% CI). Lines: COVID-19 deaths (ICD10 U071), 2020; colors are stratified by regional COVID-19 case incidence per 1,000,000 residents through July 31, 2020 (green <1,050 cases per 100,000 residents; yellow 1,050-1,499 cases per 100,000 residents; red >1,500 cases per 100,000 residents). HHS Regions: Region 1: Connecticut, Maine, Massachusetts, New Hampshire, Rhode Island, and Vermont; Region 2: New Jersey and New York; Region 3: Delaware, District of Columbia, Maryland, Pennsylvania, Virginia, and West Virginia; Region 4: Alabama, Florida, Georgia, Kentucky, Mississippi, North Carolina, South Carolina, and Tennessee; Region 5: Illinois, Indiana, Michigan, Minnesota, Ohio, and Wisconsin; Region 6: Arkansas, Louisiana, New Mexico, Oklahoma, and Texas; Region 7: Iowa, Kansas, Missouri, and Nebraska; Region 8: Colorado, Montana, North Dakota, South Dakota, Utah, and Wyoming; Region 9: Arizona, California, Hawaii, and Nevada; Region 10: Alaska, Idaho, Oregon, and Washington.

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